The adenovirus type 5 i-leader open reading frame functions in cis to reduce the half-life of L1 mRNAs.

doi:10.1128/JVI.64.2.551-558.1990

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Article

The adenovirus type 5 i-leader open reading frame functions in cis to reduce the half-life of L1 mRNAs.

Journal of virology - 1 Feb 1990

Soloway P D, Shenk T

Abstract excerpt

The 440-nucleotide adenovirus type 5 i-leader sequence, encoding a 13.6-kilodalton protein, is located between the second and third components of the tripartite leader sequence. It appears primarily on the L1 family of mRNAs. To study its function, we constructed two point mutations within the i leader. pm382 lacks the wild-type i-leader splice acceptor and failed to splice the leader onto L1 mRNAs. pm383 lacks...

Topics

Adenoviruses, Human
Animals
Base Sequence
Cell Line
Dactinomycin
Genes, Viral
Half-Life
Humans
Kinetics
Methionine
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Probes

Plasmids

Protein Sorting Signals

RNA, Messenger

Sulfur Radioisotopes

Vero Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 2296076
DOI: 10.1128/JVI.64.2.551-558.1990
PMCID: PMC249143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2296076-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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