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Identification of a New Human Adenovirus Protein Encoded by a Novel Late l -Strand Transcription Unit

20 Sept 2007

Abstract excerpt

A short open reading frame named the "U exon," located on the adenovirus (Ad) l-strand (for leftward transcription) between the early E3 region and the fiber gene, is conserved in mastadenoviruses. We have observed that Ad5 mutants with large deletions in E3 that infringe on the U exon display a mild growth defect, as well as an aberrant Ad E2 DNA-binding protein (DBP) intranuclear localization pattern and an...

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Identifiers

PMID: 17881437
DOI: 10.1128/jvi.01531-07

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