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Article

Epigenetic inactivation of IRX4 is responsible for acceleration of cell growth in human pancreatic cancer

14 Oct 2020

Abstract excerpt

Epigenetic gene silencing by aberrant DNA methylation is one of the important mechanisms leading to loss of key cellular pathways in tumorigenesis. Methyl-CpG-targeted transcriptional activation (MeTA) reactivates hypermethylation-mediated silenced genes in a different way from DNA-demethylating agents. Microarray coupled with MeTA (MeTA-array) identified seven commonly hypermethylation-mediated silenced genes in...

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Share to Cancer-related gene regulation
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PMID: 32894817
DOI: 10.1111/cas.14644

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