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Article

SEMA4A mutations lead to susceptibility to light irradiation, oxidative stress, and ER stress in retinal pigment epithelial cells.

Investigative ophthalmology & visual science - 28 Sept 2012

Tsuruma Kazuhiro, Nishimura Yuhei, Kishi Seiya, Shimazawa Masamitsu, Tanaka Toshio, Hara Hideaki

Abstract excerpt

PURPOSE: RP is a retinal degeneration disorder that is caused by mutations of various genes, including semaphorin-4A (SEMA4A). A number of retinal diseases, including RP, are associated with light exposure, oxidative stress, and endoplasmic reticulum (ER) stress. In this study, we investigated whether mutant SEMA4A causes retinal dysfunction via light exposure, oxidative stress, and ER stress. METHODS: Mutant...

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Source

Identifiers

PMID: 22956603
DOI: 10.1167/iovs.11-9378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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