Article

Vertebrate Animal Models of RP59: Current Status and Future Prospects

2022-09-22

Abstract excerpt

Retinitis pigmentosa-59 (RP59) is a rare, recessive form of RP, caused by mutations in the gene encoding DHDDS (dehydrodolichyl diphosphate synthase). DHDDS forms a heterotetrameric complex with Nogo-B Receptor (NgBR; gene NUS1) to form a cis-prenyltransferase (CPT) enzyme complex, which is required for synthesis of dolichol, which in turn is required for protein N-glycosylation as well as other glycosylation reac...

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Literature Corpus work: c5135b1b-d92a-5379-842b-0f543e269849
DOI: 10.20944/preprints202209.0339.v1

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