Article
Type-II collagen gene expression is transiently upregulated in experimentally induced degeneration of rabbit intervertebral disc.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Jul 1997
Takaishi H, Nemoto O, Shiota M, Kikuchi T, Yamada H, Yamagishi M, Yabe Y
Abstract excerpt
To clarify phenotypic alterations of intervertebral disc cells during the repair process, we cloned partial type-II collagen cDNA from rabbits and analyzed the level of expression of type-II collagen mRNA in disc degeneration. An animal model was created by surgical denucleation of rabbit interve...
Topics
- Animals
- Blotting, Northern
- Cartilage, Articular
- Chondrocytes
- Cloning, Molecular
- Collagen
- DNA, Complementary
- Female
- Gene Expression
- In Situ Hybridization
- Intervertebral Disc
- Phenotype
- Procollagen
- RNA, Messenger
- Rabbits
- Up-Regulation