Article
Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect.
Nature genetics - 1 Dec 2005
Monsuur Alienke J, de Bakker Paul I W, Alizadeh Behrooz Z, Zhernakova Alexandra, Bevova Marianna R, Strengman Eric, Franke Lude, van't Slot Ruben, van Belzen Martine J, Lavrijsen Ineke C M, Diosdado Begoña, Daly Mark J, Mulder Chris J J, Mearin M Luisa, Meijer Jos W R, Meijer Gerrit A, van Oort Erica, Wapenaar Martin C, Koeleman Bobby P C, Wijmenga Cisca
Abstract excerpt
Celiac disease is probably the best-understood immune-related disorder. The disease presents in the small intestine and results from the interplay between multiple genes and gluten, the triggering environmental factor. Although HLA class II genes explain 40% of the heritable risk, non-HLA genes a...
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