Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Early emergence and selection of a SIV-LTR C/EBP site variant in SIV-infected macaques that increases virus infectivity.

PloS one - 1 Jan 2012

Ravimohan Shruthi, Gama Lucio, Engle Elizabeth L, Zink M Christine, Clements Janice E

Abstract excerpt

CCAAT/enhancer binding protein (C/EBP)β, and C/EBP binding sites in the HIV/SIV-long terminal repeat (LTR) are crucial for regulating transcription and for IFNβ-mediated suppression of virus replication in macrophages, the predominant source of productive virus replication in the brain. We invest...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CCAAT-Enhancer-Binding Proteins
Share to Interferon-beta
Share to Interleukin-6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macaca

Share to Simian Acquired Immunodeficiency Syndrome

Share to Simian Immunodeficiency Virus

Share to Spleen

Share to Terminal Repeat Sequences

Source

Open in PubMed Open full text

Identifiers

PMID: 22952612
DOI: 10.1371/journal.pone.0042801
PMCID: PMC3428313

Genes

EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22952612-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early emergence and selection of a SIV-LTR C/EBP site variant in SIV-infected macaques that increases virus infectivity.PMID 22952612Read ↗

Identification and characterization of a macrophage-tropic SIV envelope glycoprotein variant in blood from early infection in SIVmac251-infected macaques.Semantic proximity Read ↗

Analysis of simian immunodeficiency virus sequence variation in tissues of rhesus macaques with simian AIDSSemantic proximity Read ↗

Characterization of simian immunodeficiency virus (SIV) that induces SIV encephalitis in rhesus macaques with high frequency: role of TRIM5 and major histocompatibility complex genotypes and early entry to the brain.Semantic proximity Read ↗

Pathogenesis of SIV pneumonia: selective replication of viral genotypes in the lung.Semantic proximity Read ↗

Changes in simian immunodeficiency virus reverse transcriptase alleles that appear during infection of macaques enhance infectivity and replication in CD4+ T cells.Semantic proximity Read ↗

Pathogenesis of SIV encephalitis. Selection and replication of neurovirulent SIV.Semantic proximity Read ↗

Microglia and macrophages alterations in the CNS during acute SIV infection: A single-cell analysis in rhesus macaquesSemantic proximity Read ↗

Unique pattern of convergent envelope evolution in simian immunodeficiency virus-infected rapid progressor macaques: association with CD4-independent usage of CCR5.Semantic proximity Read ↗

Progressive selection for neurovirulent genotypes in the brain of SIV-infected macaques.Semantic proximity Read ↗

Reactivation of simian immunodeficiency virus reservoirs in the brain of virally suppressed macaquesSemantic proximity Read ↗

Tissue-Specific Sequence Alterations in the Human Immunodeficiency Virus Type 1 Envelope Favoring CCR5 Usage Contribute to Persistence of Dual-Tropic Virus in the BrainSemantic proximity Read ↗

Mechanism for the Establishment of Transcriptional HIV Latency in the Brain in a Simian Immunodeficiency Virus–Macaque ModelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.