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Depression Trajectories, Genetic Risk, and Cognitive Performance in Older Adults: Multilevel Model with a 10-Year Longitudinal Cohort.

Gerontology - 1 Jan 2023

Liu Zheran, Su Yonglin, Huang Rendong, Li Ruidan, Wei Zhigong, He Ling, Pei Yiyan, Min Yu, Hu Xiaolin, Peng Xingchen

Abstract excerpt

INTRODUCTION: Cognitive performance in older ages is strongly affected by individuals' genetic predispositions. We investigated whether depression trajectories were associated with subsequent cognitive performance independent of participants' genetic predispositions. METHODS: Participants from the Health and Retirement Study with European ancestry and aged over 50 were included in the analysis. Depressive...

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Apolipoprotein E4
Cognition
Cognitive Dysfunction
Depression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Longitudinal Studies

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PMID: 36944316
DOI: 10.1159/000530200

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