Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cognitive Trajectory Changes Over 20 Years Before Dementia Diagnosis: A Large Cohort Study.

Journal of the American Geriatrics Society - 1 Dec 2017

Li Ge, Larson Eric B, Shofer Jane B, Crane Paul K, Gibbons Laura E, McCormick Wayne, Bowen James D, Thompson Mary Lou

Abstract excerpt

BACKGROUND/OBJECTIVES: Longitudinal studies have shown an increase in cognitive decline many years before clinical diagnosis of dementia. We sought to estimate changes, relative to "normal" aging, in the trajectory of scores on a global cognitive function test-the Cognitive Abilities Screening Instrument (CASI). DESIGN: A prospective cohort study. SETTING: Community-dwelling members of a U.S. health maintenance...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins E

Share to Cognition

Share to Cognitive Dysfunction

Share to Dementia

Share to Disease Progression

Share to Time Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 28940184
DOI: 10.1111/jgs.15077
PMCID: PMC5729097

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cognitive Trajectory Changes Over 20 Years Before Dementia Diagnosis: A Large Cohort Study.PMID 28940184Read ↗

Progression of cognitive, functional, and neuropsychiatric symptom domains in a population cohort with Alzheimer dementia: the Cache County Dementia Progression study.Semantic proximity Read ↗

A Longitudinal Item Response Theory Model to Characterize Cognition Over Time in Elderly Subjects.Semantic proximity Read ↗

Predicting Cognitive Decline in Early Alzheimer’s: Insights from East Asian CohortsSemantic proximity Read ↗

Heterogeneity of cognitive trajectories in diverse older persons.Semantic proximity Read ↗

Identification of and a Prediction Model for Cognitive Trajectories in Patients With Mild Cognitive Impairment Due to Alzheimer’s DiseaseSemantic proximity Read ↗

Sequence of decline on the NIH-toolbox cognitive battery in a predominantly Latino sample with autosomal dominant Alzheimer's disease.Semantic proximity Read ↗

Effect of Alzheimer's disease risk genes on trajectories of cognitive function in the Cardiovascular Health Study.Semantic proximity Read ↗

Lipid Trajectories Improve Risk Models for Alzheimer’s Disease and Mild Cognitive ImpairmentSemantic proximity Read ↗

Predicting Cognitive Decline across Four Decades in Mutation Carriers and Non-carriers in Autosomal-Dominant Alzheimer's Disease.Semantic proximity Read ↗

Trajectories of memory decline in preclinical Alzheimer's disease: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of ageing.Semantic proximity Read ↗

Pre-clinical cognitive phenotypes for Alzheimer disease: a latent profile approach.Semantic proximity Read ↗

Trajectories of amyloid beta accumulation - Unveiling the relationship with APOE genotype and cognitive decline.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.