Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population.

doi:10.1038/s41598-019-53654-9

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Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population.

Scientific reports - 22 Nov 2019

Low Siew-Kee, Chin Yoon Ming, Ito Hidemi, Matsuo Keitaro, Tanikawa Chizu, Matsuda Koichi, Saito Hiroko, Sakurai-Yageta Mika, Nakaya Naoki, Shimizu Atsushi, Nishizuka Satoshi S, Yamaji Taiki, Sawada Norie, Iwasaki Motoki, Tsugane Shoichiro, Takezaki Toshiro, Suzuki Sadao, Naito Mariko, Wakai Kenji, Kamatani Yoichiro, Momozawa Yukihide, Murakami Yoshinori, Inazawa Johji, Nakamura Yusuke, Kubo Michiaki, Katagiri Toyomasa, Miki Yoshio

Abstract excerpt

Genome-wide association studies (GWAS) have successfully identified about 70 genomic loci associated with breast cancer. Owing to the complexity of linkage disequilibrium and environmental exposures in different populations, it is essential to perform regional GWAS for better risk prediction. This study aimed to investigate the genetic architecture and to assess common genetic risk model of breast cancer with...

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PMID: 31757997
DOI: 10.1038/s41598-019-53654-9
PMCID: PMC6874604

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