Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer.

doi:10.1073/pnas.1110977109

Article

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer.

Proceedings of the National Academy of Sciences of the United States of America - 18 Sept 2012

Tucci Paola, Agostini Massimiliano, Grespi Francesca, Markert Elke K, Terrinoni Alessandro, Vousden Karen H, Muller Patricia A J, Dötsch Volker, Kehrloesser Sebastian, Sayan Berna S, Giaccone Giuseppe, Lowe Scott W, Takahashi Nozomi, Vandenabeele Peter, Knight Richard A, Levine Arnold J, Melino Gerry

Abstract excerpt

p63 inhibits metastasis. Here, we show that p63 (both TAp63 and ΔNp63 isoforms) regulates expression of miR-205 in prostate cancer (PCa) cells, and miR-205 is essential for the inhibitory effects of p63 on markers of epithelial-mesenchymal transition (EMT), such as ZEB1 and vimentin. Correspondin...

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Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer.

Abstract excerpt

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