Article
Nuclear iASPP may facilitate prostate cancer progression.
Cell death & disease - 23 Oct 2014
Morris E V, Cerundolo L, Lu M, Verrill C, Fritzsche F, White M J, Thalmann G N, ten Donkelaar C S, Ratnayaka I, Salter V, Hamdy F C, Lu X, Bryant R J
Abstract excerpt
One of the major challenges in prostate cancer (PCa) research is the identification of key players that control the progression of primary cancers to invasive and metastatic disease. The majority of metastatic PCa express wild-type p53, whereas loss of p63 expression, a p53 family member, is a common event. Here we identify inhibitor of apoptosis-stimulating protein of p53 (iASPP), a common cellular regulator of...
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