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Article

p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model.

PloS one - 1 Jan 2013

Olsen Jan Roger, Oyan Anne Margrete, Rostad Kari, Hellem Margrete R, Liu Jie, Li Lisha, Micklem David R, Haugen Hallvard, Lorens James B, Rotter Varda, Ke Xi-Song, Lin Biaoyang, Kalland Karl-Henning

Abstract excerpt

The transcription factor p63 is central for epithelial homeostasis and development. In our model of epithelial to mesenchymal transition (EMT) in human prostate cells, p63 was one of the most down-regulated transcription factors during EMT. We therefore investigated the role of p63 in EMT. Over-expression of the predominant epithelial isoform ΔNp63α in mesenchymal type cells of the model led to gain of several...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23658742
DOI: 10.1371/journal.pone.0062547
PMCID: PMC3641034

Genes

MET
ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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