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Article

Caspase-3 as a therapeutic target for heart failure

8 Jan 2013

Abstract excerpt

INTRODUCTION: Heart failure is a condition with significant morbidity and high mortality. It is likely to become unmanageable in the rapidly increasing aging population, due mainly to lack of effective treatment. Apoptosis is one of the major mechanisms causing cardiomyocyte loss in the failing hearts of both human patients and animal models. Thus, anti-apoptosis has been proposed as a provocative new concept for...

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PMID: 23294432
DOI: 10.1517/14728222.2013.745513

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