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Article

Effect of coffee combining green coffee bean constituents with typical roasting products on the Nrf2/ARE pathway in vitro and in vivo.

Journal of agricultural and food chemistry - 26 Sept 2012

Volz Nadine, Boettler Ute, Winkler Swantje, Teller Nicole, Schwarz Christoph, Bakuradze Tamara, Eisenbrand Gerhard, Haupt Larissa, Griffiths Lyn R, Stiebitz Herbert, Bytof Gerhard, Lantz Ingo, Lang Roman, Hofmann Thomas, Somoza Veronika, Marko Doris

Abstract excerpt

This study investigated Nrf2-activating properties of a coffee blend combining raw coffee bean constituents with 5-O-caffeoylquinic acid (CGA) as a lead component with typical roasting products such as N-methylpyridinium (NMP). In cell culture (HT29) the respective coffee extract (CN-CE) increased nuclear Nrf2 translocation and enhanced the transcription of ARE-dependent genes as exemplified for NAD(P)H:quinone...

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Source

Identifiers

PMID: 22946519
DOI: 10.1021/jf302258u

Genes

CGA
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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