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High Consumption of Coffee Disrupts Nonhomologous End Joining Implications for Genomic Stability

2026-04-07

Abstract excerpt

Caffeine, the most widely consumed stimulant worldwide and primarily sourced from coffee, is well known for its central nervous system effects. Emerging evidence indicates that caffeine also modulates key cellular processes, including DNA repair. It inhibits the kinase activity of ATM and ATR-essential DNA damage response proteins, and impairs homologous recombination (HR)-mediated repair through multiple mechanis...

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Literature Corpus work
c3b1c0ff-fa37-5a83-af91-1250bedddd04
DOI
10.64898/2026.04.05.716533
Open publication

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