Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of antioxidative Nrf2 gene transcription by coffee in humans: depending on genotype?

Molecular biology reports - 1 Jun 2012

Boettler Ute, Volz Nadine, Teller Nicole, Haupt Larisa M, Bakuradze Tamara, Eisenbrand Gerhard, Bytof Gerhard, Lantz Ingo, Griffiths Lyn R, Marko Doris

Abstract excerpt

The Nrf2/ARE pathway is a major cellular defense mechanism that prevents damage by reactive oxygen species through induction of antioxidative phase II enzymes. However, the activity of the Nrf2/ARE system is not uniform with variability in response presumed to be dependent on the Nrf2 genotype. We recently completed a pilot human coffee intervention trial with healthy humans, where large interindividual...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antioxidants
Share to Caffeine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coffee

Share to DNA Damage

Share to Glutathione

Share to Leukocytes

Share to NF-E2-Related Factor 2

Share to Transcriptional Activation

Source

Identifiers

PMID: 22314914
DOI: 10.1007/s11033-012-1547-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of antioxidative Nrf2 gene transcription by coffee in humans: depending on genotype?PMID 22314914Read ↗

Effect of coffee combining green coffee bean constituents with typical roasting products on the Nrf2/ARE pathway in vitro and in vivo.Semantic proximity Read ↗

Identification of polymorphisms in the promoter region of the human NRF2 gene.Semantic proximity Read ↗

Modulation of inflammatory gene transcription after long-term coffee consumptionSemantic proximity Read ↗

[Functional polymorphism of NRF2 gene promoter -617C/A in lipopolysaccharide-stimulated peripheral blood mononuclear cellular inflammatory response in patients with alcoholic liver disease].Semantic proximity Read ↗

Nrf2-dependent gene expression is affected by the proatherogenic apoE4 genotype-studies in targeted gene replacement mice.Semantic proximity Read ↗

Polymorphisms of Nrf2, an antioxidative gene, are associated with blood pressure in Japanese.Semantic proximity Read ↗

The rs12594956 polymorphism in the NRF-2 gene is associated with top-level Spanish athlete's performance status.Semantic proximity Read ↗

NRF2 genotype improves endurance capacity in response to training.Semantic proximity Read ↗

Interaction between SNPs in the NRF2 gene and elite endurance performance.Semantic proximity Read ↗

NFE2L2 Gene Variants and Arsenic Susceptibility: A Lymphoblastoid Model.Semantic proximity Read ↗

[Effects of NF-E2-related factor-2 promoter polymorphism on lipopolysaccharide-induced inflammatory responses in macrophages].Semantic proximity Read ↗

Genetic variability in iron-related oxidative stress pathways (Nrf2, NQ01, NOS3, and HO-1), iron intake, and risk of postmenopausal breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.