Article
[Stoichiometric model of folate-dependent metabolism of one-carbon units in human placenta].
Ukrains'kyi biokhimichnyi zhurnal (1999 ) - 1 Jan 2000
Rodrihes R R, Lushchyk I S, Obolens'ka M Iu
Abstract excerpt
The work is dedicated to creation of the mathematical model of folate-dependent one-carbon unit metabolism (FOCM) and study of its function in human placenta under homocysteine load and the most common mutations in the genes of methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS). In the model we have taken into account specific features of placental expression of genes that encode...
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