Article
GOLPH3 is essential for contractile ring formation and Rab11 localization to the cleavage site during cytokinesis in Drosophila melanogaster.
PLoS genetics - 1 May 2014
Sechi Stefano, Colotti Gianni, Belloni Giorgio, Mattei Vincenzo, Frappaolo Anna, Raffa Grazia D, Fuller Margaret T, Giansanti Maria Grazia
Abstract excerpt
The highly conserved Golgi phosphoprotein 3 (GOLPH3) protein has been described as a Phosphatidylinositol 4-phosphate [PI(4)P] effector at the Golgi. GOLPH3 is also known as a potent oncogene, commonly amplified in several human tumors. However, the molecular pathways through which the oncoprotei...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Cytokinesis
- Drosophila Proteins
- Drosophila melanogaster
- Humans
- Molecular Sequence Data
- Mutation
- Sequence Homology, Amino Acid
- Spindle Apparatus
- rab GTP-Binding Proteins