Article
Genetic and molecular basis of quantitative trait loci of arthritis in rat: genes and polymorphisms.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2008
Xiong Qing, Jiao Yan, Hasty Karen A, Stuart John M, Postlethwaite Arnold, Kang Andrew H, Gu Weikuan
Abstract excerpt
Rheumatoid arthritis (RA) is an autoimmune disease, the pathogenesis of which is affected by multiple genetic and environmental factors. To understand the genetic and molecular basis of RA, a large number of quantitative trait loci (QTL) that regulate experimental autoimmune arthritis have been identified using various rat models for RA. However, identifying the particular responsible genes within these QTL...
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