Article
Ataxia telangiectasia mutated impacts insulin-like growth factor 1 signalling in skeletal muscle.
Experimental physiology - 1 Feb 2013
Ching James Kain, Luebbert Stephen H, Collins Roy L, Zhang Zhihong, Marupudi Nandhini, Banerjee Sankha, Hurd Robin D, Ralston Lyle, Fisher Jonathan S
Abstract excerpt
Reports that ataxia telangiectasia mutated (ATM) is required for full activation of Akt raise the hypothesis that ATM plays a role in insulin-like growth factor 1 (IGF-1) signalling through the Akt/mammalian target of rapamycin (mTOR) pathway. Differentiated C2C12 cells harbouring either ATM-targeting short hairpin RNA (shRNA) or non-targeting shRNA and myotubes from a C2C12 lineage previously exposed to empty...
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