Article
Role of ataxia telangiectasia mutated in insulin signalling of muscle-derived cell lines and mouse soleus.
Acta physiologica (Oxford, England) - 1 Apr 2010
Jeong I, Patel A Y, Zhang Z, Patil P B, Nadella S T, Nair S, Ralston L, Hoormann J K, Fisher J S
Abstract excerpt
AIM: Ataxia telangiectasia mutated (ATM) reportedly plays a role in insulin-stimulated activation of Akt in some cell types but not in others. The role of ATM in insulin signalling has not been firmly resolved for skeletal muscle cells, for which Akt phosphorylation is a pivotal step in stimulation of glucose transport. Accordingly, our aim was to determine the role of ATM in insulin effects for cell lines...
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