Article
Dimethylthiourea inhibition of B16 melanoma growth and induction of phenotypic alterations; relationship to ATP levels.
British journal of cancer - 1 Apr 1991
Fux A, Sidi Y, Kessler-Icekson G, Wasserman L, Novogrodsky A, Nordenberg J
Abstract excerpt
1,3 Dimethylthiourea (DMTU) has previously been shown by us to inhibit the growth of melanoma cells and to induce phenotypic alterations in these cells, including ultrastructural alterations of mitochondria. These findings raised the possibility that impaired mitochondrial function might be invol...
Topics
- Adenosine Triphosphate
- Animals
- Cell Division
- Drug Resistance
- Electron Transport Complex IV
- Lactates
- Melanoma, Experimental
- Methylurea Compounds
- Mice
- Phenotype
- Sodium-Potassium-Exchanging ATPase
- Thiourea
- Tumor Cells, Cultured