Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells Is Primarily Due To Isoform ALDH1A3 and Its Expression Is Predictive of Metastasis

23 Nov 2010

Abstract excerpt

Cancer stem cells (CSCs) are proposed to initiate cancer and propagate metastasis. Breast CSCs identified by aldehyde dehydrogenase (ALDH) activity are highly tumorigenic in xenograft models. However, in patient breast tumor immunohistological studies, where CSCs are identified by expression of ALDH isoform ALDH1A1, CSC prevalence is not correlative with metastasis, raising some doubt as to the role of CSCs in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer, Hypoxia, and Metabolism
Share to Cancer, Stress, Anesthesia, and Immune Response

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21280157
DOI: 10.1002/stem.563

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells Is Primarily Due To Isoform ALDH1A3 and Its Expression Is Predictive of MetastasisPMID 21280157Read ↗

Aldehyde dehydrogenase: Its role as a cancer stem cell marker comes down to the specific isoformSemantic proximity Read ↗

ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell ProgramSemantic proximity Read ↗

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.Semantic proximity Read ↗

High expression of stem cell marker ALDH1 is associated with reduced BRCA1 in invasive breast carcinomas.Semantic proximity Read ↗

Hypoxia promotes the phenotypic change of aldehyde dehydrogenase activity of breast cancer stem cellsSemantic proximity Read ↗

The Concept of Cancer Stem Cells: Elaborating on ALDH1B1 as an Emerging Marker of Cancer ProgressionSemantic proximity Read ↗

ALDHHigh Breast Cancer Stem Cells Exhibit a Mesenchymal-Senescent Hybrid Phenotype, with Elevated Metabolic and Migratory Activities.Semantic proximity Read ↗

Breast cancer stem cells expressing different stem cell markers exhibit distinct biological characteristics.Semantic proximity Read ↗

In Situ Identification of Putative Cancer Stem Cells by Multiplexing ALDH1, CD44, and Cytokeratin Identifies Breast Cancer Patients with Poor PrognosisSemantic proximity Read ↗

ALDH1A Isozymes are Markers of Human Melanoma Stem Cells and Potential Therapeutic TargetsSemantic proximity Read ↗

Moving forward in human mammary stem cell biology and breast cancer prognostication using ALDH1.Semantic proximity Read ↗

Stem Cell Marker Aldehyde Dehydrogenase 1 (ALDH1)-Expressing Cells are Enriched in Triple-Negative Breast CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.