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Article

Global Methylation Patterns in Idiopathic Pulmonary Fibrosis

10 Apr 2012

Abstract excerpt

BACKGROUND: Idiopathic Pulmonary Fibrosis (IPF) is characterized by profound changes in the lung phenotype including excessive extracellular matrix deposition, myofibroblast foci, alveolar epithelial cell hyperplasia and extensive remodeling. The role of epigenetic changes in determining the lung phenotype in IPF is unknown. In this study we determine whether IPF lungs exhibit an altered global methylation...

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PMID: 22506007
DOI: 10.1371/journal.pone.0033770

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