Article
Giant cell tumor occurring in familial Paget's disease of bone: report of clinical characteristics and linkage analysis of a large pedigree.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 2013
Gianfrancesco Fernando, Rendina Domenico, Merlotti Daniela, Esposito Teresa, Amyere Mustapha, Formicola Daniela, Muscariello Riccardo, De Filippo Gianpaolo, Strazzullo Pasquale, Nuti Ranuccio, Vikkula Mikka, Gennari Luigi
Abstract excerpt
Neoplastic degeneration represents a rare but serious complication of Paget's disease of bone (PDB). Although osteosarcomas have been described in up to 1% of PDB cases, giant cell tumors are less frequent and mainly occur in patients with polyostotic disease. We recently characterized a large pedigree with 14 affected members of whom four developed giant cell tumors at pagetic sites. The high number of affected...
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