Article
Clinical Characteristics and Pathogenic Gene Identification in Chinese Patients With Paget's Disease of Bone.
Frontiers in endocrinology - 1 Jan 2022
Tao Xiaohui, Liu Li, Yang Xingguang, Wei Zhe, Chen Zhongzhong, Zhang Ge, Zhang Zhenlin, Yue Hua
Abstract excerpt
Objective: To evaluate the clinical features of sporadic Paget's disease of bone (PDB) in China and further explore the underlying genetic abnormalities of the disease. Methods: Clinical characteristics, biochemical indices, bone turnover markers and radiographic examinations of the patients were collected. Genomic DNA was extracted from peripheral blood and whole-exome sequencing was carried out to identify the...
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