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Article

Ploidy and large-scale genomic instability consistently identify basal-like breast carcinomas with BRCA1/2 inactivation.

Cancer research - 1 Nov 2012

Popova Tatiana, Manié Elodie, Rieunier Guillaume, Caux-Moncoutier Virginie, Tirapo Carole, Dubois Thierry, Delattre Olivier, Sigal-Zafrani Brigitte, Bollet Marc, Longy Michel, Houdayer Claude, Sastre-Garau Xavier, Vincent-Salomon Anne, Stoppa-Lyonnet Dominique, Stern Marc-Henri

Abstract excerpt

BRCA1 inactivation is a frequent event in basal-like breast carcinomas (BLC). However, BRCA1 can be inactivated by multiple mechanisms and determining its status is not a trivial issue. As an alternate approach, we profiled 65 BLC cases using single-nucleotide polymorphism arrays to define a signature of BRCA1-associated genomic instability. Large-scale state transitions (LST), defined as chromosomal break...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22933060
DOI: 10.1158/0008-5472.CAN-12-1470

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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