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Article

Circulating nucleosomes and severity of illness in children suffering from meningococcal sepsis treated with protein C

29 Aug 2012

Abstract excerpt

OBJECTIVE: Cell death leading to circulating nucleosomes and histones is a critical step in the pathogenesis of sepsis and contributes to lethality. Activated protein C was demonstrated to attenuate the harmful effects of histones. The objective of this retrospective study was to evaluate whether nucleosomes correlate with the severity of the inflammatory response and mortality in children suffering from severe...

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PMID: 22932399
DOI: 10.1097/ccm.0b013e318265695f

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