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Article

Protein C promoter polymorphisms associate with sepsis in children with systemic meningococcemia.

Human genetics - 1 Sept 2007

Binder Alexander, Endler Georg, Rieger Sandra, Geishofer Gotho, Resch Bernhard, Mannhalter Christine, Zenz Werner

Abstract excerpt

Meningococcal disease may present as sepsis, meningitis or a combination of both. Protein C (PC) is an important regulator of thrombin activity. Two polymorphisms in the promoter region of PC (C-1654T, A-1641G) have been shown to affect PC levels. In patients with meningococcal sepsis, low PC lev...

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Identifiers

PMID: 17569089
DOI: 10.1007/s00439-007-0392-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17569089-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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