Article
Absence of a red blood cell phenotype in mice with hematopoietic deficiency of SEC23B.
Molecular and cellular biology - 1 Oct 2014
Khoriaty Rami, Vasievich Matthew P, Jones Morgan, Everett Lesley, Chase Jennifer, Tao Jiayi, Siemieniak David, Zhang Bin, Maillard Ivan, Ginsburg David
Abstract excerpt
Congenital dyserythropoietic anemia type II (CDAII) is an autosomal recessive disease of ineffective erythropoiesis characterized by increased bi/multinucleated erythroid precursors in the bone marrow. CDAII results from mutations in SEC23B. The SEC23 protein is a core component of coat protein complex II-coated vesicles, which transport secretory proteins from the endoplasmic reticulum to the Golgi apparatus....
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