Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Secreted GDF15 maintains transcriptional responses during DNA damage-mediated senescence in human beta cells

28 Aug 2024

Abstract excerpt

Beta cell senescence is an emerging contributor to the pathogenesis of type 1 diabetes, but candidate therapeutic targets have not been identified in human beta cells. In this study, we examined the role of a secreted factor, GDF15, and found that although it is not required to maintain viability during senescence, it is required to fine-tune gene expression programs involved in the senescence response during DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to GDF15 and Related Biomarkers
Share to Genetics and Neurodevelopmental Disorders
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39196800
DOI: 10.1152/ajpendo.00257.2024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Secreted GDF15 maintains transcriptional responses during DNA damage-mediated senescence in human beta cellsPMID 39196800Read ↗

Senescence of human pancreatic beta cells enhances functional maturation through chromatin reorganization and promotes interferon responsivenessSemantic proximity Read ↗

Unique Human and Mouse β-Cell Senescence-Associated Secretory Phenotype (SASP) Reveal Conserved Signaling Pathways and Heterogeneous FactorsSemantic proximity Read ↗

Deletion of Gdf15 Reduces ER Stress-induced Beta-cell Apoptosis and DiabetesSemantic proximity Read ↗

Accumulation of SA-βGal–High Cells in Human Naïve T Cell Compartments Reveals a Stress-Adapted, Senescent-Like StateSemantic proximity Read ↗

Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes InterventionSemantic proximity Read ↗

Growth and differentiation factor-15: A link between inflammaging and cardiovascular diseaseSemantic proximity Read ↗

GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cellsSemantic proximity Read ↗

Role of GDF15/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in OsteoarthritisSemantic proximity Read ↗

DNA Damage and Senescence-Associated Inflammation in Cardiovascular DiseaseSemantic proximity Read ↗

DNA sensing in senescence.Semantic proximity Read ↗

IGFBP5 is released by senescent cells and is internalized by healthy cells, promoting their senescence through interaction with retinoic receptorsSemantic proximity Read ↗

Depletion of growth differentiation factor 15 ( GDF15 ) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblastsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.