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Kcnh1 Voltage-gated Potassium Channels Are Essential for Early Zebrafish Development

28 Aug 2012

Abstract excerpt

The Kcnh1 gene encodes a voltage-gated potassium channel highly expressed in neurons and involved in tumor cell proliferation, yet its physiological roles remain unclear. We have used the zebrafish as a model to analyze Kcnh1 function in vitro and in vivo. We found that the kcnh1 gene is duplicated in teleost fish (i.e. kcnh1a and kcnh1b) and that both genes are maternally expressed during early development. In...

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PMID: 22927438
DOI: 10.1074/jbc.m112.363978

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