Article
Functional analysis of KCNH2 gene mutations of type 2 long QT syndrome in larval zebrafish using microscopy and electrocardiography.
Heart and vessels - 1 Jan 2019
Tanaka Yoshihiro, Hayashi Kenshi, Fujino Noboru, Konno Tetsuo, Tada Hayato, Nakanishi Chiaki, Hodatsu Akihiko, Tsuda Toyonobu, Nagata Yoji, Teramoto Ryota, Yoshida Shohei, Nomura Akihiro, Kawashiri Masa-Aki, Yamagishi Masakazu
Abstract excerpt
Heterologous expression systems play a vital role in the characterization of potassium voltage-gated channel subfamily H member 2 (KCNH2) gene mutations, such as E637K which is associated with long QT syndrome type 2 (LQT2). In vivo assays using zebrafish provide a means for testing genetic variants of cardiac disease; however, limited information on the role of the E637K mutation is available from in vivo...
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