Article
Identification of a novel HLA-A2-restricted mutated Survivin epitope and induction of specific anti-HCC CTLs that could effectively cross-recognize wild-type Survivin antigen.
Cancer immunology, immunotherapy : CII - 1 Feb 2013
Shen Han, Shao Hong-Wei, Chen Xiao-Hua, Wu Feng-Lin, Wang Hui, Huang Zhao-Liang, Shen Juan, Wang Teng, Zhang Wen-Feng, Huang Shu-Lin
Abstract excerpt
Peptide vaccine based on tumor-associated antigen (TAA), which usually belongs to self-antigen with poor immunogenicity, has been considered as an attractive option for treatment of malignant tumors. The ideal TAA epitopes should have stable affinity to major histocompatibility complex (MHC) molecules and elicit strong anti-tumor immune response. Although point-mutation technology of TAA peptide may increase the...
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