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Article

MHC-restricted fratricide of human lymphocytes expressing survivin-specific transgenic T cell receptors

1 Nov 2010

Abstract excerpt

The apoptosis inhibitor protein survivin is overexpressed in many tumors, making it a candidate target molecule for various forms of immunotherapy. To explore survivin as a target antigen for adoptive T cell therapy using lymphocytes expressing survivin-specific transgenic T cell receptors (Tg-TCRs), we isolated HLA-A2-allorestricted survivin-specific T cells with high functional avidity. Lymphocytes expressing...

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PMID: 20978348
DOI: 10.1172/jci43437

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