Article
A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder.
Journal of affective disorders - 20 Feb 2013
Lee Heon-Jeong, Woo Hyun Goo, Greenwood Tiffany A, Kripke Daniel F, Kelsoe John R
Abstract excerpt
OBJECTIVE: The use of subphenotypes may be an effective approach for genetic studies of complex diseases. Manic episodes with a seasonal pattern may distinguish phenotypic subgroups of bipolar subjects that may also differ genetically. METHOD: We have performed a genome-wide association study using GAIN genotype data from the Bipolar Genome Study (BiGS) and bipolar subjects that were categorized as having either...
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