Article
Identification of a potential bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4.
Molecular psychiatry - 1 Oct 2005
Glaser B, Kirov G, Bray N J, Green E, O'Donovan M C, Craddock N, Owen M J
Abstract excerpt
The gene encoding the transcription factor RFX4 represents an excellent neurobiological and positional candidate gene for Bipolar disorder due to the potential involvement of RFX4 proteins in the regulation of circadian rhythms and the proximity of the locus to numerous linkage signals on chromosome 12q23. In this study we have sought to identify common variants within the gene, which might confer risk to the...
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