Article
Familiality of polarity at illness onset in bipolar affective disorder.
The American journal of psychiatry - 1 Oct 2006
Kassem Layla, Lopez Victor, Hedeker Don, Steele Jo, Zandi Peter, McMahon Francis J
Abstract excerpt
OBJECTIVE: Bipolar affective disorder is clinically heterogeneous, and clinical features that run in families may help define more homogeneous phenotypes. The authors sought to establish whether polarity at illness onset, which is related to severity and course, is a familial feature of bipolar affective disorder. METHOD: The authors studied 971 subjects from 507 families ascertained through sibling pairs with...
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