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Article

Parent-of-origin effects of A1CF and AGO2 on testicular germ-cell tumors, testicular abnormalities, and fertilization bias.

Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 2016

Carouge Delphine, Blanc Valerie, Knoblaugh Sue E, Hunter Robert J, Davidson Nicholas O, Nadeau Joseph H

Abstract excerpt

Testicular tumors, the most common cancer in young men, arise from abnormalities in germ cells during fetal development. Unconventional inheritance for testicular germ cell tumor (TGCT) risk both in humans and mice implicates epigenetic mechanisms. Apolipoprotein B mRNA-editing enzyme complex 1 (APOBEC1) cytidine deaminase and Deadend-1, which are involved in C-to-U RNA editing and microRNA-dependent mRNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasms, Germ Cell and Embryonal

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Source

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Identifiers

PMID: 27582469
DOI: 10.1073/pnas.1604773113
PMCID: PMC5027451

Genes

AGO2
APOBEC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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