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CRISPR-mediated genome editing of Plasmodium falciparum malaria parasites

25 Aug 2014

Abstract excerpt

The development of the CRISPR-Cas system is revolutionizing genome editing in a variety of organisms. The system has now been used to manipulate the genome of Plasmodium falciparum, the most lethal malaria-causing species. The ability to generate gene deletions or nucleotide substitutions rapidly and economically promises to accelerate the analysis of novel drug targets and to help elucidate the function of...

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PMID: 25473431
DOI: 10.1186/s13073-014-0063-9

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