Article
Extracellular Matrix Remodeling in Atopic Dermatitis Harnesses the Onset of an Asthmatic Phenotype and Is a Potential Contributor to the Atopic March.
The Journal of investigative dermatology - 1 May 2024
Graff Patrick, Woerz Dana, Wilzopolski Jenny, Voss Anne, Sarrazin Jana, Blimkie Travis M, Weiner January, Kershaw Olivia, Panwar Preety, Hackett Tillie, Lau Susanne, Brömme Dieter, Beule Dieter, Lee Young-Ae, Hancock Robert E W, Gruber Achim D, Bäumer Wolfgang, Hedtrich Sarah
Abstract excerpt
The development of atopic dermatitis in infancy, and subsequent allergies, such as asthma in later childhood, is known as the atopic march. The mechanism is largely unknown, however the course of disease indicates an inter-epithelial crosstalk, through the onset of inflammation in the skin and progression to other mucosal epithelia. In this study, we investigated if and how skin-lung epithelial crosstalk...
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