Article
From the morphological to the transcriptomic characterization of a compromised three-dimensional in vitro model mimicking atopic dermatitis.
The British journal of dermatology - 1 Oct 2015
Rouaud-Tinguely P, Boudier D, Marchand L, Barruche V, Bordes S, Coppin H, Roth M P, Closs B
Abstract excerpt
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease in which skin barrier function is disrupted. In this AD environment, proinflammatory cytokines are upregulated, promoting a vicious circle of inflammation. Although several three-dimensional in vitro models mimicking AD have been published, no study has presented a fully characterized and controlled model of AD-related inflammation....
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