Isolation and partial characterization of cyclosporin synthetase from a cyclosporin non-producing mutant of Beauveria nivea.

doi:10.1515/bchm3.1990.371.2.829

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Article

Isolation and partial characterization of cyclosporin synthetase from a cyclosporin non-producing mutant of Beauveria nivea.

Biological chemistry Hoppe-Seyler - 1 Sept 1990

Dittmann J, Lawen A, Zocher R, Kleinkauf H

Abstract excerpt

Cyclosporin synthetase was isolated from a cyclosporin non-producing mutant of Beauveria nivea, strain YP 582. The enzyme has a molecular mass in the range of active cyclosporin synthetase and also contains 4'-phosphopantetheine as a prosthetic group. It is able to activate all constituent amino...

Topics

Amino Acid Sequence
Cyclosporins
Fungi
Methylation
Molecular Sequence Data
Multienzyme Complexes
Mutation
Pantetheine
Peptide Synthases

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