Article
Isolation of (4R)-4-[(E)-2-butenyl]-4-methyl-L-threonine, the characteristic structural element of cyclosporins, from a blocked mutant of Tolypocladium inflatum.
The Journal of antibiotics - 1 Jun 1990
Sanglier J J, Traber R, Buck R H, Hofmann H, Kobel H
Abstract excerpt
By mutagenic treatment of a strain of Tolypocladium inflatum, a cyclosporin non-producing mutant was obtained which accumulated the characteristic building unit of cyclosporins, (4R)-4-[(E)-2-butenyl]-4-methyl-L-threonine (abbreviation Bmt; systematic name: (2S,3R,4R,6E)-2-amino-3-hydroxy-4-methy...
Topics
- Chemical Phenomena
- Chemistry
- Cyclosporins
- Magnetic Resonance Spectroscopy
- Mass Spectrometry
- Mitosporic Fungi
- Molecular Structure
- Mutation
- Spectrophotometry, Infrared
- Threonine
- Ultraviolet Rays