Article
Differences in signaling through the B-cell leukemia oncoprotein CRLF2 in response to TSLP and through mutant JAK2.
Blood - 4 Oct 2012
van Bodegom Diederik, Zhong Jun, Kopp Nadja, Dutta Chaitali, Kim Min-Sik, Bird Liat, Weigert Oliver, Tyner Jeffrey, Pandey Akhilesh, Yoda Akinori, Weinstock David M
Abstract excerpt
Approximately 10% of B-cell acute lymphoblastic leukemias (B-ALLs) overexpress the cytokine receptor subunit CRLF2, which may confer a poor prognosis. CRLF2 binds its ligand thymic stromal lymphopoietin (TSLP) as a heterodimer with IL7R. Subsets of CRLF2-overexpressing B-ALLs also have a gain-of-function CRLF2 F232C mutation or activating mutations in JAK2. Whether these mutant alleles confer differences in...
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