Article

Selective dependency of CALR-mutant myeloproliferative neoplasms on TYK2 signaling

2026-01-07

Abstract excerpt

<title>Abstract</title> <p> Myeloproliferative neoplasms (MPN) are driven by the oncoproteins JAK2V617F, mutant calreticulin (CALR), and mutant thrombopoietin receptor (TPOR), all of which activate JAK/STAT signaling. While JAK2 signaling is engaged in all MPNs, TYK2 is dispensable for JAK2V617F-driven disease. Here, we hypothesized a distinct role for TYK2 in CALR-mutant driven MPN. We found constitutive TYK2 p...

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Literature Corpus work: dca15bfd-ab6c-53a4-a88d-69f51800c0a8
DOI: 10.21203/rs.3.rs-8425696/v1

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