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Article

A role for iron-sulfur clusters in the regulation of transcription factor Yap5-dependent high iron transcriptional responses in yeast.

The Journal of biological chemistry - 12 Oct 2012

Li Liangtao, Miao Ren, Bertram Sophie, Jia Xuan, Ward Diane M, Kaplan Jerry

Abstract excerpt

Yeast respond to increased cytosolic iron by activating the transcription factor Yap5 increasing transcription of CCC1, which encodes a vacuolar iron importer. Using a genetic screen to identify genes involved in Yap5 iron sensing, we discovered that a mutation in SSQ1, which encodes a mitochondr...

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Identifiers

PMID: 22915593
DOI: 10.1074/jbc.M112.395533
PMCID: PMC3471690

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-22915593-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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