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Article

A heme-sensing mechanism in the translational regulation of mitochondrial cytochrome c oxidase biogenesis.

Cell metabolism - 5 Dec 2012

Soto Iliana C, Fontanesi Flavia, Myers Richard S, Hamel Patrice, Barrientos Antoni

Abstract excerpt

Heme plays fundamental roles as cofactor and signaling molecule in multiple pathways devoted to oxygen sensing and utilization in aerobic organisms. For cellular respiration, heme serves as a prosthetic group in electron transfer proteins and redox enzymes. Here we report that in the yeast Saccharomyces cerevisiae, a heme-sensing mechanism translationally controls the biogenesis of cytochrome c oxidase (COX), the...

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Identifiers

PMID: 23217259
DOI: 10.1016/j.cmet.2012.10.018
PMCID: PMC3523284

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